Chondromyxoid fibroma cmf is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. All structured data from the file and property namespaces is available under the creative commons cc0 license. Chondromyxoid fibroma at an unusual site srevatsa k, kangle rp. In this case, only histology of the biopsy was useful in diagnosing cmf before definitive surgery. Chondromyxoid fibroma like osteosarcoma cmfos is an exceedingly rare subtype of lowgrade.
Frank, dds,d iowa city, iowa university of iowa chondromyxoid fibroma is a benign tumor of bone that is characterized by chondroid and. The ultrastructural study exhibited stellate, ovoid or elongated tumor cells with features of cartilage cells and abundant loose matrix with many fine filamentous structures. However, the case presented here is an extremely rare case as the tumor affected the middle and upper segment of the humerus. A wide subtotal resection of the sternum and reconstruction with a. Case report open access chondromyxoid fibroma like osteosarcoma. Chondromyxoid fibroma cmf is one of the rarest benign tumors of. Chondromyxoid fibroma of the sacrum and left iliac bone. Pdf chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin.
An 11yearold girl presented to our opd with complaints. Chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up case description. Jaffe and lichtenstein first described the condition in 1943. The most helpful diagnostic feature is the nodular architecture of myxoid. Chondromyxoid fibroma cmf is a relatively uncommon benign bone tumor of cartilaginous differentiation. Activating rearrangements of grm1 metabotropic glutamate receptor 1. Chondromyxoid fibromas cmfs are extremely rare, benign cartilaginous neoplasms that account for chondromyxoid fibroma. Chondromyxoid fibroma cmf is a rare benign neoplasm of cartilaginous origin. It occurs most frequently in the metaphysis of long tubular bones, and an epiphyseal location is exceedingly rare. In this paper, we present a case of femoral chondromyxoid fibroma and discuss the rational reason for high accumulation of 18ffdg by petct in accordance with histology. Chondromyxofibroma cmf is exceedingly rare, accounting. It is extremely rare and accounts for less that 1% of all bone tumors. Chondromyxoid fibroma cmf is a benign cartilage tumor that also has myxoid and fibrous elements. Chondromyxoid fibroma is a rare tumor which comprises less than 1% of all benign bone tumors, and it is the least common benign cartilaginous tumor of.
Chondromyxoid fibroma is a rare benign primary bone tumor of cartilage. A resected case of chondromyxoid fibroma of the right fibula in a 31. Fineneedle aspiration biopsy of chondromyxoid fibroma. Chondromyxoid fibroma cmf is a rarely encountered benign bone chondroid tumor. The histology was composed of characteristic lobular features of this tumor with abundant cartilaginous matrix. Chondromyxoid fibroma cmf was first described by jaffe and lichtenstein 1. Differential diagnosis of cartilaginous lesions of bone archives of. As the name suggests, chondromyxoid fibroma shows chondroid, myxomatous, and fibrous zones. Specimens from cases of chondromyxoid fibromas from the mayo bone tumor registry, rochester, mn, and the. A rare case of juxtacortic chondromyxoid fibroma in. Chondromyxoid fibroma cmf is an unusual bone tumor first. Cementoossifying fibroma cof is a distinct form of a benign fibroosseous tumor, affecting predominantly the craniofacial region.
Chondroblastoma differential diagnoses medscape reference. The histological sections showed mitochondrion lobules with increased cellularity in the peripheral area. A rare case of epiphyseal chondromyxoid fibroma of the. Chondromyxoid fibroma is often misdiagnosed being a radiological and pathological mimicker. The histopathology result confirmed the diagnosis of chondromyxoid fibroma. Chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin. Plain film and mri appearances, histology and treatment are described. Hence, to explore the clinical manifestations, diagnostic tests, and therapeutic procedures for temporal bone cartilage myxoid fibroma, it is important to optimize patient treatment and avoid overtreatment. Chondromyxoid fibroma cmf is one of the rarest of bone tumors, accounting for less than 1% of all bone tumors. A chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. Acta orthop sand 57,375377,1986 chondromyxoid fibroma of the foot a report of a missed diagnosis james r. It is a benign noncancerous tumor that most often develops in older children and young adults under 30 years of age. Biopsy confirmed a chondromyxoid fibroma which was removed surgically. Plain film radiograph shows lytic, oval, bubbly lesion with sclerotic rims.
On mri, surrounding minimal bone marrow oedema may be seen. Metaphysis of long bones is the most common location of this tumor. Files are available under licenses specified on their description page. Lemmens a chondromyxoid fibroma in th calcaneus of an 11year old girl wa pri marily diagnosed as a solitary bone cyst. Acknowledgment we thank barbara almarez mahinda for secretarial support. Chondromyxoid fibroma of the sacrum and left iliac bone ajr. Chondromyxoid fibroma cmf is a rare, benign bone tumour. Chondromyxoid fibroma cmf is a rare form of benign bone tumor and easily misdiagnosed as fibrosarcoma. They are so close in histology that often radiology helps to make the final diagnosis. It is composed of a mixture of chondroid, myxoid, and fibrous tissues. We report a case of a 35yearold female with a 3 month history of lower back pain after sustaining a fall on her sacrumcoccyx presenting with a progressive complaint of localized lower back pain, occasional urinary retention without incontinence, gluteal hypesthesia, and.
Chondromyxoid fibroma is a type of cartilaginous tumor most cases are characterised by grm1 gene fusion or promoter swapping. Cell biology and matrix biochemistry of chondromyxoid fibroma. Typical radiographic features include bubbly lucency and sclerotic rim located eccentrically within the metaphysis of long bones commonly the tibia. The tumor has a lobular growth pattern with lobules of varying sizes as seen in this image. In 1931, codman classified it as a chondromatous variant of giant cell tumors, when he described these lesions in the proximal humerus. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or. We report the second case of chondromyxoid fibroma cmf of the sternum, documented in the literature. This rare benign tumor has a striking predilection for the bones of the tibia and the foot. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings may mimic more. Cementoossifying fibroma was initially classified by the world health organization who as a fibroosseous neoplasm.
Chondromyxoid fibroma of the maxillofacial region is typically seen in patients. It is associated with high local recurrence rates with a small risk chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. It accounts for less than 1 percent of all bone tumors and approximately 95 percent of these cases are seen in metaphysis of long bone. Occasional osteoclastlike giant multinucleated cells are encountered. Chondroblastoma and chondromyxoid fibroma abstract chondroblastoma and chondromyxoid. Background chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up chondromyxoid fibroma cmf is a rare, slowgrowing, benign bone tumor of chondroblastic derivation. Definition and pathogenesis 1st described by jaffe and lichtenstein in 1948 previously classified as myxoma of bone bloodgood1924 or myxomatous variant of gct arises from the cartilageforming connective tissue of the marrow aberrations of 6q within t. A 30yearold man with a 7month history of mild sacral pain and intermittant left sciatica was found to have an expansile lesion in the sacrum on a plain radiograph. The primary pitfall in the histopathologic diagnosis of cmf. The lobules have a hypocellular center with condensation of tumor cells at the periphery. However, no paper has explained the reason for this high accumulation. The margin of a completely resected chondromyxoid fibroma is microscopically sharply demarcated, either by bone or connective tissue if the tumor has eroded through the bone. Nora lesion is a reactive periostitis that mimics osteochondroma and is discussed with this group of lesions.
Benign cartilage lesions can be divided into those that differentiate towards fetal type cartilage chondroblastoma and chondromyxoid fibroma and those that differentiate towards mature hyaline type cartilage osteochondroma, chondroma. Chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. We present here an unusual case of a chondromyxoid fibroma that occurred in the epiphysis of the proximal tibia with an open growth plate. Epidemiology imaging histopathology course and staging treatment. However, there a few case reports of this tumor arising from epiphysis of short tubular bones of the hand and feet. In 1948, the tumor was first described by jaffe and lichtenstein as a lesion derived from cartilageforming tissue and composed of various proportions of chondroid, fibrous, and myxoid tissues. It has a predilection for men in the second and third decades of life with the metaphyseal regions of the long bones of the lower extremities as the favored sites of occurrence. Chondromyxoid fibroma cmf is a rare, benign and potentially. Chondromyxoid fibroma cmf is a benign neoplasm accounting for fewer than 1% of all bone tumors. Well circumscribed, hypocellular lobules of poorly formed hyaline cartilage composed of chondroblasts with abundant pink cytoplasm and myxoid tissue with fibrous septae containing spindle cells and osteoclasts. Chondromyxoid fibroma is a benign tumor composed of spindle or stellate cells forming lobules. Chondromyxoid fibroma is an uncommon benign cartilaginous tumor of the bone.